Nirogacestat (PF-03084014, PF-3084014), ≥99.99%,Nirogacestat (PF-03084014, PF-3084014)
中文名称: Nirogacestat (PF-03084014, PF-3084014), ≥99.99%
英文名称: Nirogacestat (PF-03084014, PF-3084014)
Cas号:1290543-63-3
MDL号:MFCD19980705
分子式:C27H41F2N5O
分子量:489.64
Beilstein编号:
EINECS编号:
储存条件:-20℃
增值税发票√顺丰快递√订货电话:18601927057
品牌货号 | CAS No. | 包装 | 报价 | 库存 |
---|---|---|---|---|
1290543-63-3 | 5mg | ¥996.00 | 杭州 北京(现货) | |
1290543-63-3 | 10mg | ¥1736.00 | 杭州 北京(现货) | |
1290543-63-3 | 25mg | ¥3612.00 | 杭州 北京(现货) | |
1290543-63-3 | 50mg | ¥5887.00 | 杭州 北京(现货) |
用途: | Nirogacestat (PF-03084014, PF-3084014) 是一种选择性gamma-secretase抑制剂,在无细胞试验中IC50为6.2 nM。Phase 2。PF-03084014 inhibits Notch receptor cleavage in cellular assays using HPB-ALL cells that harbor mutations in both the heterodimerization and PEST domains in Notch1with IC50 of 13.3 nM. PF-03084014 downregulates Notch target genes Hes-1, and cMyc expression in HPB-ALL cells with IC50 of <1 nM and 10 nM, respectively. PF-03084014 inhibits cell growth of a subset of human T-ALL cell lines (HPB-ALL, DND-41, TALL-1,and Sup-T1) through induction of cell cycle arrest and apoptosis with IC50s of 30-100 nM. [1]PF-03084014 reduces proliferation of HUVECs with IC50 of 0.5 μM, and decreases the lumen formation with an IC50 value of 50 nM. PF-03084014 (1 μM) has no antiproliferative effect in MX1 cells; however, it inhibits migration by 95%. |
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储存条件: | -20℃ |
颜色: | 粉末 |
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